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Wiest DL , Berger MA , Carleton M
Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?
Seminars in Immunology. 1999 Aug;11(4) :251-262
Abstractbeta-selection refers to a developmental checkpoint linking thymocyte survival to the outcome of antigen receptor gene rearrangement. Immature thymocytes that productively rearrange the gene segments of the TCR beta locus undergo proliferative expansion and mature to the CD4(+) CD8(+) stage; those failing to do so die by apoptosis. How are these precursor cells alerted that TCR beta rearrangement has been productive? While it is clear that this process involves signals transduced by a surrogate form of the TCR termed the pre-TCR, it remains unclear how pre-TCR signals are triggered. In this review, we will discuss the implications of recent experimental attempts to address this issue, as well as how pre-TCR activation is linked to the changes in gene expression that underlie thymocyte development.
NotesTimes Cited: 11 English Review 228CB SEMIN IMMUNOL