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Padanilam BJ , Stadler HS , Mills KA , McLeod LB , Solursh M , Lee B , Ramirez F , Buetow KH , Murray JC
Characterization of the human HOX 7 cDNA and identification of polymorphic markers
Human Molecular Genetics. 1992 ;1(6) :407-410
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cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.
09646906 (ISSN) Cited By: 29; Export Date: 31 May 2006; Source: Scopus CODEN: HMGEE Language of Original Document: English Correspondence Address: Padanilam, B.J.; Department of Biology; University of Iowa Iowa City, IA 52242, United States Molecular Sequence Numbers: GENBANK: M88632, M88633, M88634, M88635, M88636, M88637, M97676, X64597, X64598, X64599; Chemicals/CAS: DNA, 9007-49-2; RNA, 63231-63-0, Deoxyribonucleases, Type II Site-Specific, EC; DNA, 9007-49-2; endodeoxyribonuclease EcaI, EC 3.1.21.-; endodeoxyribonuclease MboII, EC 3.1.21.-; Oligodeoxyribonucleotides; RNA, 63231-63-0