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Mahabir S , Baer DJ , Johnson LL , Frenkel K , Dorgan JF , Cambell W , Hartman TJ , Clevidence B , Albanes D , Judd JT , Taylor PR
No association between alcohol supplementation and autoantibodies to DNA damage in postmenopausal women in a controlled feeding study
European Journal of Cancer Prevention. 2005 ;14(4) :427-429
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Alcohol consumption is linked to increased breast cancer risk. Since oestrogens increase breast cancer risk, possibly through oxidative damage, and we have shown that alcohol consumption increases serum oestrogens, we tested whether moderate alcohol supplementation increased oxidative DNA damage among healthy postmenopausal women not on hormone replacement therapy in a randomized controlled crossover study. We used serum 5-hydroxymethyl-2-deoxyuridine (5-HMdU) autoantibodies (aAbs) as a marker of oxidative DNA damage. The results showed no evidence for increased or decreased levels of oxidative DNA damage among women who consumed 15 g or 30 g alcohol per day for 8 weeks compared with women in the 0 g alcohol group. We conclude that among healthy women, it is possible that an 8-week trial of moderate alcohol supplementation might be too short to make enough 5-HMdU aAbs to compare differences by alcohol dose. In future studies, a panel of biomarkers for DNA damage should be used. © 2005 Lippincott Williams & Wilkins.
09598278 (ISSN) Cited By: 0; Export Date: 25 May 2006; Source: Scopus CODEN: EJUPE; DOI: 10.1097/00008469-200508000-00017 Language of Original Document: English Correspondence Address: Mahabir, S.; Department of Epidemiology; CPB4.3247; UT MD Anderson Cancer Center; 1155 Pressler Blvd Houston, TX 77030, United States; email: smahabir@mdanderson.org Chemicals/CAS: 5 hydroxymethyldeoxyuridine, 5116-24-5, Alcohols; Autoantibodies; Biological Markers References: Baer, D., Judd, J., Clevidence, B., Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet (2002) Am J Clin Nutr, 75, pp. 593-599; Cavalieri, E., Frenkel, K., Liehr, J., Rogan, E., Roy, D., Estrogens as endogenous genotoxic agents - DNA adducts and mutations (2000) J Natl Cancer Inst Monogr, 27, pp. 75-93; Djuric, Z., Heilbrun, L., Lababidi, S., Levels of 5-hydroxymethyl-2-deoxyuridine in DNA from blood of women scheduled for breast biopsy (2001) Cancer Epidemiol Biomarkers Prev, 10, pp. 147-149; Dorgan, J., Baer, D., Albert, P., Serum hormones and the alcohol-breast cancer association in postmenopausal women (2001) J Natl Cancer Inst, 93, pp. 710-715; Frenkel, K., Khasak, D., Karkoszka, J., Shupack, J., Stiller, M., Enhanced antibody titers to an oxidized DNA base in inflammatory and neoplastic diseases (1992) Exp Dermatol, 1, pp. 242-247; Frenkel, K., Karkoszka, J., Kim, E., Taioli, E., Recognition of oxidized DNA bases by sera of patients with inflammatory diseases (1993) Free Radic Biol Med, 14, pp. 483-494; Frenkel, K., Karkoszka, J., Glassman, T., Serum autoantibodies recognizing 5-hydroxymethyl-2-deoxyuridine, an oxidized DNA base, as biomarker of cancer risk in women (1998) Cancer Epidemiol Biomarkers Prev, 7, pp. 49-57; Wallstrom, P., Frenkel, K., Wirfalt, E., Antibodies against 5-hydroxymethyl-2-deoxyuridine are associated with lifestyle factors and GSTM1 genotype: A report from the Malmo diet and cancer cohort (2003) Cancer Epidemiol Biomarkers Prev, 12, pp. 444-451.