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Ma CM , Veltchev I , Fourkal E , Li JS , Luo W , Fan J , Lin T , Pollack A
Development of a laser-driven proton accelerator for cancer therapy
Laser Physics. 2006 ;16(4) :639-646
PMID: AN 2006:336910   
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Recent advances in laser technol. have made proton (light ion) acceleration possible using laser-induced plasmas. In this work, we report our work for the last few years on the investigation of a new proton therapy system for radiation oncol., which employs laser-accelerated protons. If successfully developed, the new system will be compact, cost-effective, and capable of delivering energy-and intensity-modulated proton therapy (EIMPT). We have focused our research on three major aspects: (1) target design for laser-proton acceleration, (2) system design for particle/energy selection and beam collimation, and (3) dosimetric studies on the use of laser-accelerated protons for cancer therapy. We have performed particle-in-cell (PIC) simulations to investigate optimal target configurations for proton/ion acceleration. We also performed Monte Carlo simulations to study the beam characteristics and the feasibility of using such beams for cancer treatment. Since laser-accelerated protons have broad energy and angular distributions, which are not suitable for radiotherapy applications directly, we have designed a compact particle selection and beam collimating system for EIMPT beam delivery. We also proposed a new gantry design to make the whole system compact to retrofit existing linac vaults. We have compared Monte Carlo calcd. dose distributions using X-ray IMRT and laser-proton EIMPT. Our results show that EIMPT using laser protons produces superior target coverage and much reduced crit. structure dose and integral dose compared to X-ray IMRT. [on SciFinder (R)]
71 Nuclear Technology Radiation Oncology Department,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal 1054-660X written in English.