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Blumberg Baruch S
The curiosities of hepatitis B virus: Prevention, sex ratio, and demography
Proceedings of the American Thoracic Society. 2006 ;3(1) :14-20
PMID: AN 2006:309586
AbstractHepatitis B virus (HBV) is a deadly pathogenic agent with complex and subtle interactions with its host that are not pathol. The host responses to HBV infection are largely affected by a series of polymorphic alleles at several loci on the human genome, and these loci are also related to other infections. HBV affects the sex ratio in populations, both at birth and later in life. The effects of these dynamic systems on the demog., population biol., and microevolution can be profound. Males infected with HBV are more likely to become carriers of the virus while infected females are more likely to develop anti-HBs. In countries with high HBV prevalence (such as China), the decreased no. of females born, the so-called lost women demog. observation, may due more to the high prevalence of the virus and less to other factors. National vaccination programs targeting HBV have been in place since the early 1980s. These programs have decreased the spread of HBV, particularly in China and East Asia, resulting in a dramatic decline in morbidity from liver disease and saving millions of people from dying. HBV vaccination appears to prevent primary cancer of the liver, and is the first widely used preventive cancer vaccine. [on SciFinder (R)]
Notes10 Microbial, Algal, and Fungal Biochemistry Fox Chase Cancer Center,Philadelphia,PA,USA. Journal 1546-3222 written in English.