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Matullo Christine M , Rall Glenn F
Immunological wrong turns in the face of multiple viral challenges
Future Virology. 2006 ;1(1) :37-45
PMID: AN 2006:253945   
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To further understand the myriad of ways by which viruses can cause disease, development of new and creative model systems using lab. mice will be required. Mouse models have been essential tools for the study of viral pathogenesis over the past 50 years, allowing for detailed assessments of viral replication, spread and immune response induction. However, virtually all of these studies were accomplished using a single-challenge approach, in which immunol. naive adult mice were inoculated with only one pathogen. This approach, while useful for exploring individual pathogen-host interactions, does not parallel the complexity of immune history and potential concurrent immune challenges that occur in humans. This review discusses current progress in viral pathogenesis using the single-challenge approach, followed by an overview of the present understanding of how concurrent immune challenges may influence pathogenesis. It is suggested that the development of more complex mouse models will be a substantial advance, leading to the discovery of previously unappreciated aspects of immune cell recruitment and novel ways by which viruses can, either directly or indirectly, promote illness. [on SciFinder (R)]
15 Immunochemistry Division of Basic Science, Viral Pathogenesis Program,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal 1746-0794 written in English.