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Morgan RO , Bell DW , Testa JR , Fernandez MP
Human annexin 31 genetic mapping and origin
Gene. 1999 Feb 4;227(1) :33-38
PMID: ISI:000078556900004   
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Abstract
The cDNA encoding novel human annexin 31 was utilized for chromosomal mapping, structural comparison, and phylogenetic analysis to clarify its genetic relationship to other annexins. The ANX31 gene locus was mapped by fluorescence in situ hybridization to human chromosome 1q21, remote from ten other paralogous human annexins on different chromosomes but near the epidermal differentiation gene complex, the S100A gene cluster and a breast-cancer translocation region. Protein homology testing and characterization of incompletely processed expressed sequence tags identified annexin 2 as the closest extant homologue. Maximum likelihood analysis confirmed its most recent common ancestor with vertebrate annexin 2 and validated its classification, in order of discovery, as annexin 31. This subfamily was formed approx. 500-600 million years ago, subsequent to the gene duplication that produced annexin 1. It has diverged rapidly and extensively, especially in the well-conserved and functionally critical type II calcium- binding sites. (C) 1999 Elsevier Science B.V. All rights reserved.
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Times Cited: 5 English Article 166BT GENE