This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Chen JQ , Yager JD , Russo J
Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications
Biochimica Et Biophysica Acta-Molecular Cell Research. 2005 Oct 30;1746(1) :1-17
AbstractIt is well known that the biological and carcinogenic effects of 17 beta-estradiol (E-2) are mediated via nuclear estrogen receptors (ERs) by regulating nuclear gene expression. Several rapid, non-nuclear genomic effects of E-2 are mediated via plasma membrane-bound ERs. In addition, there is accumulating evidence suggesting that mitochondria are also important targets for the action of estrogens and ERs. This review summarized the studies on the effects of estrogens via ERs on mitochondrial structure and function. The potential physiological and pathophysiological implications of deficiency and/or overabundance of these E-2/ER-mediated mitochondrial effects in stimulation of cell proliferation, inhibition of apoptosis, E-2-mediated cardiovascular and neuroprotective effects in target cells are also discussed. (c) 2005 Elsevier B.V All rights reserved.