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Dresler CM , Fratelli C , Babb J
Prognostic value of positive pleural lavage in patients with lung cancer resection
Annals of Thoracic Surgery. 1999 May;67(5) :1435-1439
PMID: ISI:000080548200053   
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Background. Despite an early stage, lung cancer patients often have a poor survival, suggesting inaccurate staging. A pleural lavage demonstrating malignant cells at the time of operation may predict a poorer survival, particularly in patients with otherwise early disease. Methods. Patients, with no preoperative evidence of pleural effusions and undergoing a surgical resection with curative intent, had a preresectional and postresectional lavage to be evaluated by cytology. Results. Fourteen percent of patients with stage I disease had malignant cells in their preresectional lavage and had a significantly shorter survival than stage I patients with a negative lavage. Positivity of preresectional lavage was not correlated with nodal status, pleural or lymphatic involvement, or histologic findings. Conclusions. Preoperative pleural lavage should become a standard technique intraoperatively to better characterize and stage patients undergoing lung cancer resections. Patients with malignant cells in their preoperative lavage should be upstaged. (Ann Thorac Surg 1999;67:1435-9) (C) 1999 by The Society of Thoracic Surgeons.
Times Cited: 5 English Article 200PE ANN THORAC SURG