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Skalka AM , Katz RA
Retroviral DNA integration and the DNA damage response
Cell Death and Differentiation. 2005 ;12(S1) :971-978
PMID: AN 2005:557534
AbstractRetroviral DNA integration creates a discontinuity in the host cell chromatin and repair of this damage is required to complete the integration process. As integration and repair are essential for both viral replication and cell survival, it is possible that specific interactions with the host DNA repair systems might provide new cellular targets for human immunodeficiency virus therapy. Various genetic, pharmacol., and biochem. studies have provided strong evidence that postintegration DNA repair depends on components of the nonhomologous end-joining (NHEJ) pathway (DNA-PK (DNA-dependent protein kinase), Ku, Xrcc4, DNA ligase IV) and DNA damage-sensing pathways (Atr (Atm and Rad related), g-H2AX). Furthermore, deficiencies in NHEJ components result in susceptibility to apoptotic cell death following retroviral infection. Here, we review these findings and discuss other ways that retroviral DNA intermediates may interact with the host DNA damage signaling and repair pathways.Cell Death and Differentiation (2005) 12, 971-978. [on SciFinder (R)]
Notes3 Biochemical Genetics Fox Chase Cancer Center,Institute for Cancer Research, 333 Cottman Avenue,Philadelphia,PA,USA. Journal 1350-9047 written in English.