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Cvetkovic Dusica
Early events in ovarian oncogenesis
Reproductive Biology and Endocrinology. 2003 ;1 :No pp given
PMID: AN 2005:385455   
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Ovarian cancer represents the most lethal of the gynecol. neoplasms. The mol. and genetic events assocd. with early ovarian oncogenesis are still largely unknown, thus contributing to the lack of reliable biomarkers for disease detection. Since the majority of ovarian tumors are diagnosed at an advanced stage, the availability of early ovarian cancer tissue samples for mol. analyses is very limited. In this review, problems encountered in the study of early ovarian cancer are presented, along with the controversies concerning precursor lesions and stepwise progression towards ovarian malignancy. Exptl. modeling in the development of ovarian cancer is also described, as well as genetic and epigenetic alterations assocd. with early ovarian cancer. Lastly, examples of technol. advances in the study of early ovarian cancer are discussed. Hopefully, the increasing knowledge about mol. and genetic events involved in the early stages of ovarian tumorigenesis will provide the basis for management of ovarian cancer in the future. [on SciFinder (R)]
14 Mammalian Pathological Biochemistry Ovarian Cancer Program, Division of Medical Science,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal; Online Computer File 1477-7827 written in English.