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Battista S , Fidanza V , Fedele M , Klein-Szanto AJP , Outwater E , Brunner H , Santoro M , Croce CM , Fusco A
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis
Cancer Research. 1999 Oct 1;59(19) :4793-4797
AbstractRearrangements of the HMGI-C gene have frequently been detected in human benign tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook domains and an acidic COOH-terminal tail, The HMGI-C modifications consist in the loss of the C-tail and the fusion with ectopic sequences, Recent results show that the loss of the COOH-terminal region, rather than the acquisition of new sequences, is sufficient to confer to HMGI-C the ability to transform NIH3T3 cells. Therefore, transgenic mice carrying a HMGI-C construct (HMGI- C/T), containing only the three AT-hook domains, were generated. The HIMGI-C/T mice showed a giant phenotype, together,vith a predominantly abdominal/pelvic lipomatosis, suggesting a pivotal role of the HMGI-C truncation in the generation of human lipomas.
NotesTimes Cited: 26 English Article 244AC CANCER RES