This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Moss Eric G
Noncoding RNAs. 2003 :99-116
PMID: AN 2004:841459
AbstractMicroRNAs are the smallest functional noncoding RNAs of plants and animals. They are about 22 nucleotides in length with no common structural or sequence features. Some are conserved across great evolutionary distances, indicating that their sequence is not arbitrary. A single organism may have hundreds of distinct microRNAs, some of which are expressed in stage-, tissue- or cell type-specific patterns. MicroRNAs are believed to act through specific complementary sites in target mRNAs to inhibit gene expression post-transcriptionally. Because of their size and potential to exist in almost any sequence, microRNAs are a versatile means for controlling gene expression both in nature and artificially. [on SciFinder (R)]
Notes3 Biochemical Genetics Cell and Developmental Biology,Fox Chase Cancer Center,Philadelphia,PA,USA. Conference written in English.