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Robinson MK , Weiner LM , Adams GP
Improving monoclonal antibodies for cancer therapy
Drug Development Research. 2004 Mar;61(3) :172-187
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AbstractMonoclonal antibodies have emerged as a promising class of pharmaceuticals for the treatment of many human diseases, including cancer. Historically, an inability to target monoclonal antibodies to solid tumors in sufficient quantities and with high enough specificity has hampered the effectiveness of antibodies as therapeutics. This review focuses on recent efforts in the field of antibody-engineering directed at improving both the targeting of antibody-based therapeutics as well as enhancing the efficacy of those therapeutics once they have been targeted to tumor. (C) 2004 Wiley-Liss, Inc.
NotesEnglish Review Author Keywords: cancer; monoclonal antibodies; single-chain Fv; immunotherapy WILEY-LISS; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA Subject Category: CHEMISTRY, MEDICINAL; PHARMACOLOGY & PHARMACY 0272-4391