FCCC LOGO Faculty Publications
Monk RJ , Meyuhas O , Perry RP
Mammals have multiple genes for individual ribosomal proteins
Cell. 1981 May;24(2) :301-6
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The reiteration frequency of the genes that encode the structural proteins of the mammalian ribosome was studied with a set of cloned cDNA probes containing several different mouse r-protein mRNA sequences. Results from a reassociation kinetics analysis, Southern blotting experiments and gene cloning studies collectively indicate that each individual r-protein species is represented by multiple genes in mammals. Among the examples studied, the multiplicity of mouse r-protein genes varied from about 7 to 20, a striking contrast to the low copy numbers observed in less evolutionarily advanced eucaryotes. The multiplicity of individual r-protein genes in humans and rodents is similar.
0092-8674 Journal Article