FCCC LOGO Faculty Publications
Coleclough C , Perry RP , Karjalainen K , Weigert M
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
Nature. 1981 Apr 2;290(5805) :372-8
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A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
0028-0836 Journal Article