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Coleclough C , Perry RP , Karjalainen K , Weigert M
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
Nature. 1981 Apr 2;290(5805) :372-8
PMID: 6783959 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6783959
AbstractA study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
Notes0028-0836 Journal Article