FCCC LOGO Faculty Publications
Gallo JM
Pharmacokinetics: model structure and transport systems
Transport processes in pharmaceutical systems. 2000 ;102 :55-86
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A review with 61 refs. is presented regarding model structure and transport systems in pharmacokinetics. Pharmacokinetic anal. of drug disposition in vivo offers a variety of techniques that vary from simple to complex. It behooves the experimentalist to delineate the pharmacokinetic information that is to be collected from each study and the intended method of anal. to ensure that the study design is robust and that the stated objectives can be achieved. All of the compartmental modeling approaches require anal. or numerical solns. to a system of differential equations. Anal. solns. readily incorporate statistical optimization functions helpful in model selection. Numerical solns. indicative of nonlinear systems or organ-based models, such as physiol. pharmacokinetic models, do not rely on a single dogma in model development but rather on greater input from the investigator. Nonetheless, these models should still employ and take advantage of statistical tools to develop and validate the models. Regardless of the modeling strategy, a plethora of computer programs are available and provide an optimum format for model development. The combination of modeling methods and computer packages provides ample tools for drug disposition to be addressed at any level of sophistication. [on SciFinder (R)]
edited by Gordon L. Amidon, Ping I. Lee, Elizabeth M. Topp. ill. ; Includes bibliographical references and index. ix, 727