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Van Horn L , Obarzanek E , Barton BA , Stevens VJ , Kwiterovich PO Jr , Lasser NL , Robson AM , Franklin FA Jr , Lauer RM , Kimm SY , Dorgan JF , Greenlick MR
A summary of results of the Dietary Intervention Study in Children (DISC): lessons learned
Prog Cardiovasc Nurs. 2003 Winter;18(1) :28-41
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Prevention of cardiovascular disease must begin in childhood, preferably before risk factors develop. Elevated low-density lipoprotein cholesterol levels in children are likely to track over time and become high-risk levels in adults. The Dietary Intervention Study in Children (DISC) was a multicenter, collaborative randomized trial in pre-adolescent children designed to test the efficacy and safety of a dietary intervention to lower saturated fat and cholesterol intake among growing children with elevated low-density lipoprotein cholesterol. Numerous DISC results, which include findings on lipids-lipoproteins, genetics, and nutrient adequacy, as well as descriptions of the behavioral intervention strategies, have been reported. A summary of practical findings and their potential clinical applications have not previously been published. Highlights of key lessons learned from DISC and translational applications of potential interest to nurses and other health care providers are presented.
22511798 0889-7204 Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial