This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Bailey-Wilson JE , Sorant AJ , Malley JD , Presciuttini S , Redner RA , Severini TA , Badner JA , Pajevic S , Jufer R , Baffoe-Bonnie A , Kao L , Doan BQ , Goldstein JL , Holmes TN , Behneman D , Mandal DM , Turley TN , Weissbecker KA , O'Neill J , Pugh EW
Comparison of novel and existing methods for detection of linkage disequilibrium using parent-child trios in the GAW12 genetic isolate simulated data
Genet Epidemiol. 2001 ;21 Suppl 1 :S378-83
PMID: 11793703 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11793703
AbstractA novel method for joint detection of association caused by linkage disequilibrium (LD) and estimation of both recombination fraction and linkage disequilibrium parameters was compared to several existing implementations of the transmission/disequilibrium test (TDT) and modifications of the TDT in the simulated genetic isolate data from Genetic Analysis Workshop 12. The first completely genotyped trio of affected child and parents was selected from each family in each replicate so that the TDT tests are valid tests of linkage and association, rather than being only valid as tests for linkage. In general, power to detect LD using the genome-wide scan markers was inadequate in the individual replicate samples, but the power was better when analyzing several SNP markers in candidate gene 1.
Notes21651805 0741-0395 Journal Article