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Butts K , Daniel BL , Chen L , Bouley DM , Wansapura J , Maier SE , Dumoulin C , Watkins R
Diffusion-weighted MRI after cryosurgery of the canine prostate. Magnetic resonance imaging
J Magn Reson Imaging. 2003 Jan;17(1) :131-5
PMID: 12500282 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12500282
AbstractPURPOSE: To evaluate the acute lesion created by cryosurgery with diffusion-weighted magnetic resonance imaging (DWI). MATERIALS AND METHODS: The appearance of the acute cryolesion was evaluated in four canine prostates DWI after they were warmed to original body temperature. The prostates were excised, stained with triphenyl tetrazolium chloride (TTC), photographed, prepared for hematoxylin and eosin (H&E) staining, and examined under a light microscope. RESULTS: A marked decrease in apparent diffusion coefficient of 38% was evident in the center of the previously frozen tissue, but not in all of the previously frozen tissue. Histologic results confirm differences between the iceball core and the periphery of the iceball, which have markedly different imaging characteristics on DWI. CONCLUSION: The core of the previously frozen tissue has a reduced apparent diffusion coefficient (ADC) compared to the periphery of the previously frozen tissue and previously unfrozen tissue.
Notes22387749 1053-1807 Journal Article