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Rambhatla Lakshmi , Bohn Shirley A , Stadler Patrizia B , Boyd Jonathan T , Coss Ronald A , Sherley James L
Cellular senescence: Ex vivo p53-dependent asymmetric cell kinetics
Journal of Biomedicine & Biotechnology. 2001 ;1(1) :28-37
PMID: AN 2002:53678   
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Abstract
Although senescence is a defining property of euploid mammalian cells, its physiol. basis remains obscure. Previously, cell kinetics properties of normal tissue cells have not been considered in models for senescence. The authors now provide evidence that senescence is in fact the natural consequence of normal in vivo somatic stem cell kinetics extended in culture. This concept of senescence is based on the authors' discovery that cells engineered to conditionally express the well-recognized tumor suppressor protein and senescence factor, p53, exhibit asym. cell kinetics. In vivo, asym. cell kinetics are essential for maintenance of somatic stem cells; ex vivo, the same cell kinetics yield senescence as a simple kinetic endpoint. This new \"asym. cell kinetics model\" for senescence suggests novel strategies for the isolation and propagation of somatic tissue stem cells in culture. [on SciFinder (R)]
Notes
CAN 136:229875 13-3 Mammalian Biochemistry The Molecular Oncology Group, Division of Medical Science,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal 1110-7243 written in English. 7440-66-6 (Zinc) Role: BSU (Biological study, unclassified), BIOL (Biological study) (p53-dependent asym. ex vivo cell kinetics and cellular senescence (aging)