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Testa Joseph R , Mitsuuchi Yasuhiro
Antisense molecules and small, interfering double-stranded RNA for modulation of APPL expression
. 2003 20020823. :44 pp
PMID: AN 2003:173755   
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Abstract
Compns. and methods are provided for modulating the expression of APPL. Compds. of the invention include antisense mols. and small, interfering double-stranded RNA mols. targeted to human APPL-encoding nucleic acid. The invention us useful for the treatment of human malignancy. [on SciFinder (R)]
Notes
CAN 138:215275 1-6 Pharmacology Patent written in English. 20030306 500819-26-1; 500819-27-2; 500819-28-3 Role: PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression); 500819-30-7 Role: PAC (Pharmacological activity), PRP (Properties), BIOL (Biological study) (antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression, and use with other agents in cancer treatment); 500819-29-4 Role: PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression, and use with other agents in cancer treatment); 50-18-0 (Cyclophosphamide); 57-22-7 (Vincristin); 59-05-2 (Methotrexate); 1605-68-1D (Taxane); 15663-27-1 (Cisplatin); 33069-62-4 (Taxol); 33419-42-0 (Etoposide); 41575-94-4 (Carboplatin); 180288-69-1 (Herceptin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression, and use with other agents in cancer treatment); 554-01-8 (5-Methylcytosine) Role: BSU (Biological study, unclassified), BIOL (Biological study) (oligonucleotide contg.; antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression); 500853-11-2; 500853-12-3 Role: PRP (Properties) (unclaimed nucleotide sequence; antisense mols. and small, interfering double-stranded RNA for modulation of APPL expression) A2 US 2001-314530 20010823