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Russo Irma H , Russo Jose , Deluca Giampiero , Janssens Jaak Ph
hCG therapy for the treatment of breast cancer
. 2000 19991215. :61 pp
PMID: AN 2000:420974   
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Abstract
This invention relates to the field of cancer therapy. More particularly, the invention relates to the treatment of mammary tumor, clin. manifest mammary tumor (breast cancer) and metastatic mammary tumor by administration of human Chorionic Gonadotropin (hCG). The treatment preferably comprises the administration of hCG in conjunction with an antiestrogen and/or a Type I Interferon. A protein having the biol. activity of hCG and/or a binding activity toward the hCG receptor can be used in place of hCG. Pharmaceutical compns. contg. the compds. of the invention are also claimed as are articles of manuf. comprising the pharmaceutical compns. [on SciFinder (R)]
Notes
CAN 133:38705 2-4 Mammalian Hormones Patent written in English. 20000622 9002-61-3 (Human Chorionic Gonadotropin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hCG therapy for treatment of breast cancer); 10540-29-1 (Tamoxifen) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hCG therapy in combination with an antiestrogen or a Type I interferon for treatment of breast cancer); 9002-67-9 (LH); 9002-67-9D (LH); 9002-68-0D (FSH); 9002-71-5D (TSH) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (protein having the biol. activity of hCG and/or a binding activity toward the hCG receptor for treatment of breast cancer) A2 EP 98-123817 19981215