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Adams Gregory P , Schier Robert
Developing anti-HER2/neu single-chain Fv fragments from phage display libraries
Methods in Molecular Medicine. 2000 ;39(Ovarian Cancer) :729-747
PMID: AN 2000:716528   
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A review with 19 refs. regarding a step-by-step methodol. used for the isolation, characterization, and prepn. for the in vitro evaluation and in vivo biodistributions of single-chain Fv mols. suitable for diagnosis and therapy of cancer. These techniques have been used to develop scFv-based agents specific for HER2/neu, and may also be applied to other antigen systems. [on SciFinder (R)]
CAN 134:324724 15-0 Immunochemistry Department of Medical Oncology,Fox Chase Cancer Center,Philadelphia,PA,USA. Journal; General Review written in English.