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Ye X , Adams PD
Coordination of S-phase events and genome stability
Cell Cycle. 2003 May-Jun;2(3) :185-7
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A review. New evidence indicates that completion of DNA synthesis depends upon ongoing histone synthesis and chromatin assembly. One possible explanation of this result is that repression of histone synthesis inhibits chromatin assembly which, in turn, inhibits DNA synthesis. Other data suggest that inhibition of chromatin assembly, either due to repression of histone synthesis or direct inhibition of the chromatin assembly process itself, inhibits DNA synthesis in S-phase. Thus, three major processes in S-phase-DNA synthesis, histone synthesis and chromatin assembly-appear to be mutually dependent upon each other in intact mammalian cells. [on SciFinder (R)]
22619533 1538-4101 Journal Article Review Review, Tutorial