This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Uzzo RG , Cairns P , Al-Saleem T , Hudes G , Haas N , Greenberg RE , Kolenko V
The basic biology and immunobiology of renal cell carcinoma: considerations for the clinician
Urol Clin North Am. 2003 Aug;30(3) :423-36
PMID: 12953746 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12953746
AbstractThese are indeed exciting times in the study of RCC. No longer should the clinician view RCC as a single entity, nor should the researcher pose basic questions without considering the biologic diversity of this tumor. The success of novel targeted therapeutic strategies will depend on the systematic study of genetic and epigenetic events and their relationship to aberrant protein expression and function, and an understanding of the permissive microenvironment that allows the tumor to be sustained. These studies must be correlated in a rigorous fashion to clinical parameters and outcomes. Progress against this elusive tumor will require a continuous translational dialogue between laboratory and clinical investigators.
Notes22834205 0094-0143 Journal Article Review Review Literature