FCCC LOGO Faculty Publications
Sauder JM , Dunbrack RL Jr
Genomic fold assignment and rational modeling of proteins of biological interest
Proc Int Conf Intell Syst Mol Biol. 2000 ;8 :296-306
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The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
20431603 Journal Article