This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
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Sauder JM , Dunbrack RL Jr
Genomic fold assignment and rational modeling of proteins of biological interest
Proc Int Conf Intell Syst Mol Biol. 2000 ;8 :296-306
PMID: 10977091 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10977091
AbstractThe first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
Notes20431603 Journal Article