FCCC LOGO Faculty Publications
Sauder JM , Dunbrack RL Jr
Genomic fold assignment and rational modeling of proteins of biological interest
Proc Int Conf Intell Syst Mol Biol. 2000 ;8 :296-306
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Abstract
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
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20431603 Journal Article