FCCC LOGO Faculty Publications
Henske EP , Ao X , Short MP , Greenberg R , Neumann HP , Kwiatkowski DJ , Russo I
Frequent progesterone receptor immunoreactivity in tuberous sclerosis-associated renal angiomyolipomas
Mod Pathol. 1998 Jul;11(7) :665-8
Back to previous list
Abstract
Angiomyolipomas can occur sporadically or in association with tuberous sclerosis complex (TSC). TSC is an autosomal dominant disorder characterized by seizures, mental retardation, and benign tumors of the brain, heart, kidney, and skin. Angiomyolipomas are more common in women than in men, suggesting a possible hormonal influence on tumor growth. In this study, 35 angiomyolipomas from 23 patients were immunostained with antibodies to estrogen receptor (ER) and progesterone receptor (PR). Eleven angiomyolipomas (31%) contained clusters of PR-immunoreactive smooth muscle cells. None contained ER-immunoreactive cells. Of the 21 tumors from patients with TSC, 11 (48%) were PR immunoreactive. All of the PR-immunoreactive angiomyolipomas were from women younger than 50 years of age, and all except one of these women had TSC. This study suggests that hormonal factors play a role in the pathogenesis of TSC-associated angiomyolipomas.
Notes
98351474 0893-3952 Journal Article