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Tew KD , Ronai Z
GST function in drug and stress response
Drug Resist Updat. 1999 Jun;2(3) :143-147
PMID: 11504484 URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11504484
AbstractGlutathione (GSH) is the major non-protein thiol in cells and is a co-factor for many types of conjugation reactions involving glutathione S-transferases (GST). Because of the defined role of GST in drug metabolism, elevated expression of GSTpi either as a tumor marker or in drug resistance has automatically been linked to detoxification. Similarly, GSH has mostly been viewed as a passive cellular supply of nucleophilic sulfur. This mini-review highlights recent reports which advocate a novel, non-catalytic role for GSTpi as an integral determinant of cellular pathways of stress response, proliferation and apoptosis. Copyright 1999 Harcourt Publishers Ltd.
Notes1368-7646 Journal article