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Malinow MR , Duell PB , Williams MA , Kruger WD , Evans AA , Anderson PH , Block PC , Hess DL , Upson BM , Graf EE , Irvin-Jones A , Wang LQ
Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations
Lipids. 2001 Suppl. S;36 :S27-S32
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Folic acid is presently the mainstay of treatment for most subjects with elevated plasma homocyst(e)ine concentrations [Plasma or serum homocyst(e)ine, or total homocysteine, refers to the sum of the sulfhydryl amino acid homocysteine and the homocysteinyl moieties of the disulfides homocystine and homocystein-cysteine, whether free or bound to plasma proteins.] Changes in homocyst(e)ine in response to folic acid supplementation are characterized by considerable interindividual variation. The purpose of this study was to identify factors that contribute to heterogeneity in short-term responses to folic acid supplementation. The effects of folic acid supplementation (1 or 2 mg per day) for 3 wk on plasma homocyst(e)ine concentrations were assessed in 304 men and women. Overall, folic acid supplementation increased mean plasma folate 31.5 +/- 98.0 nmol/L and decreased mean plasma homocyst(e)ine concentrations 1.2 +/- 2.4 mumol/L. There was evidence of substantial interindividual variation in the homocyst(e)ine response from -18.5 to +7.1 mumol/L, including an increase in homocyst(e)ine in 20% of subjects (mean increase 1.5 +/- 1.4 mumol/L). Basal homocyst(e)ine, age, male gender, cigarette smoking, use of multivitamins, methylene tetrahydrofolate reductase, and cystathionine beta-synthase polymorphisms accounted for 47.6% of the interindividual variability in the change in homocyst(e)ine after folic acid supplementation, but about 50% of variability in response to folic acid was not explained by the variables we studied.
Malinow, MR,Oregon Reg Primate Res Ctr, Dept Pathobiol & Immunol, 505 NW 185th Ave, Beaverton, OR 97006 USA Article English