FCCC LOGO Faculty Publications
Hardy RR
Variable Gene Usage, Physiology and Development of Ly-1+ (Cd5+) B-Cells
Current Opinion in Immunology. 1992 Apr;4(2) :181-185
PMID: ISI:A1992HZ10400010   
Back to previous list
Two related features of Ly-1+ B cells (CD5+ B cells in man) are their biased specificities and variable gene usage, and their relationship to the bulk of Ly-1- ('conventional') B cells. An emerging model views Ly-1+ B cells as a memory population in the adult animal, whose generation is largely limited to fetal and neonatal development. Selection based on germline-encoded self-reactivity then shapes the adult repertoire.
English Review HZ104 CURR OPIN IMMUNOL