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Gasser DL , Yang P , Buetow KH
Palate Teratogenicity and Embryotoxicity of Cyclosporine-a in Mice
Journal of Craniofacial Genetics and Developmental Biology. 1992 Jul-Sep;12(3) :155-158
AbstractMice of the A/J and B10. A/SgSnJ strains were treated with 50 mg of cyclosporin A (CsA) per kg of body weight on day 12 of gestation. There were significantly more fetal resorptions in both the A/J and B10.A strain when treated with CsA than in controls treated with olive oil. A low frequency (7.6%) of isolated cleft palates were induced in the A/J strain, which was significantly greater than that observed in A/J mice treated with olive oil alone. No cleft palates were induced in B10.A, which suggests that any increase in susceptibility that was observed could not be attributed to H-2 linked genes.
NotesEnglish Article JF943 J CRANIOFAC GENET DEV BIOL