FCCC LOGO Faculty Publications
Carter CL , Hu N , Wu M , Lin PZ , Murigande C , Bonney GE
Segregation Analysis of Esophageal Cancer in 221 High-Risk Chinese Families
Journal of the National Cancer Institute. 1992 May 20;84(10) :771-776
PMID: ISI:A1992HU58200014   
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Background: Until recently, environmental factors were considered of greatest importance in the etiology of esophageal cancer. Recent studies, however, have suggested that genetic factors also have a role. Purpose: Since no formal genetic study of this cancer has been previously reported, we carried out a statistical analysis to determine how important genetic factors are in the etiology of esophageal cancer in high- incidence areas of North China. Methods: Using a logistic regressive model, we performed a segregation analysis on 221 high-risk nuclear families from the Yaocun Commune, Linxian, Henan Province of China, with at least one affected family member and with all off-spring aged 40 years or older. Three models, the mendelian, the environmental, and the no- transmission models, were each compared with the general- transmission model that incorporated both genetic and environmental factors. Results: According to Akaike's Information Criterion, the mendelian model provided the best fit for the data. By the chi-square test, the mendelian inheritance model was not rejected, but the environmental and the no-transmission models were both rejected. Conclusion: The segregation analysis indicated an autosomal recessive mendelian inheritance, with the alleged mendelian gene present at a frequency of 19%, causing 4% of this population to be predisposed to develop esophageal cancer. Large, unmeasured, residual familial factors, however, were also significant. Implications: Both an autosomal recessive gene and unexplained environmental factors appear to be important in the etiology of esophageal cancer in the subpopulation studied.
English Article HU582 J NAT CANCER INST