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Tartof KD
Position Effect Variegation in Yeast
Bioessays. 1994 Oct;16(10) :713-714
PMID: ISI:A1994PP09400003   
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Abstract
Classically, position effect variegation has been studied in Drosophila and results when a euchromatic gene is placed adjacent to either centromeric heterochromatin or to a telomeric domain. In such a circumstance expression of the locus variegates, being active in some cells and silent in others. Over the last few years a comparable phenomenon in yeast has been discovered. This system promises to tell us much about this curious behavior. Indeed, experiments reported recently((1)) indicate that the variegation of a yeast telomeric gene is cell-cycle regulated. The results suggest the following model. During DNA replication there is a disassembly of chromatin that allows a competition between silencing factors and transactivators to take place. Thus, reassembly of the domain may result in either the repression or the expression of the affected gene and, hence, produce a variegating phenotype.
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English Article PP094 BIOESSAYS