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Shlomchik MJ , Madaio MP , Ni DH , Trounstein M , Huszar D
The Role of B-Cells in 1pr/1pr-Induced Autoimmunity
Journal of Experimental Medicine. 1994 Oct 1;180(4) :1295-1306
AbstractThe primacy roles of T cells and B cells in the initiation of systemic autoimmunity are unclear. To investigate the role of B cells, we crossed the ''Jh knockout'' mutation onto the autoimmune lpr/lpr background. Animals homozygous for both traits were obtained. As expected, these animals lack B cells. These animals also show no signs of autoimmune kidney destruction nor vasculitis, in spite of carrying the lpr/lpr mutation. In contrast, lpr/lpr littermates that had B cells had severe nephritis and vasculitis, as well as autoantibodies. These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune- mediated tissue destruction. The implications of this finding for models and therapy of autoimmunity are discussed.
NotesEnglish Article PJ703 J EXP MED