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McLean AR , Blumberg BS
Modeling the Impact of Mass Vaccination against Hepatitis-B .1. Model Formulation and Parameter-Estimation
Proceedings of the Royal Society of London Series B-Biological Sciences. 1994 Apr 22;256(1345) :7-15
AbstractA new model of the transmission dynamics of hepatitis B virus in countries with high transmission rates is presented. The model is age and sex stratified, and includes details of host demography. Details of hepatitis B natural history, such as the existence of infectious and non-infectious carriers, are included. The biological assumptions of the model are discussed in full and related to the model's equations. Hepatitis B epidemiological data is reviewed with special emphasis on the estimation of model parameter values from field data. A full set of model parameter values are derived. Possible uses of the model in the assessment of strategies of mass vaccination are discussed.
NotesEnglish Article NJ266 PROC ROY SOC LONDON SER B