FCCC LOGO Faculty Publications
McLean AR , Blumberg BS
Modeling the Impact of Mass Vaccination against Hepatitis-B .1. Model Formulation and Parameter-Estimation
Proceedings of the Royal Society of London Series B-Biological Sciences. 1994 Apr 22;256(1345) :7-15
PMID: ISI:A1994NJ26600002   
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Abstract
A new model of the transmission dynamics of hepatitis B virus in countries with high transmission rates is presented. The model is age and sex stratified, and includes details of host demography. Details of hepatitis B natural history, such as the existence of infectious and non-infectious carriers, are included. The biological assumptions of the model are discussed in full and related to the model's equations. Hepatitis B epidemiological data is reviewed with special emphasis on the estimation of model parameter values from field data. A full set of model parameter values are derived. Possible uses of the model in the assessment of strategies of mass vaccination are discussed.
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English Article NJ266 PROC ROY SOC LONDON SER B