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Zhang SJ , Han JH , Sells MA , Chernoff J , Knaus UG , Ulevitch RJ , Bokoch GM
Rho-Family Gtpases Regulate P38 Mitogen-Activated Protein- Kinase through the Downstream Mediator Pak1
Journal of Biological Chemistry. 1995 Oct 13;270(41) :23934-23936
AbstractThe stress-activated p38 mitogen-activated protein (MAP) kinase defines a subgroup of the mammalian MAP kinases that appear to play a key role in regulating inflammatory responses. Co- expression of constitutively active forms of Rac and Cdc42 leads to activation of p38 while dominant negative Rac and Cdc42 inhibit the ability of interleukin-1 to increase p38 activity. p21-activated kinase 1 (Pak1) is a potential mediator of Rac/Cdc42 signaling, and we observe that Pak1 stimulates p38 activity. A dominant negative Pak1 suppresses both interleukin- 1- and Rac/Cdc42-induced p38 activity. Rac and Cdc42 appear to regulate a protein kinase cascade initiated at the level of Pak and leading to activation of p38 and JNK.
NotesTimes Cited: 421 Note TA217 J BIOL CHEM