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Benson AB , D'Angelica MI , Abbott DE , Anaya DA , Anders R , Are C , Bachini M , Borad M , Brown D , Burgoyne A , Chahal P , Chang DT , Cloyd J , Covey AM , Glazer ES , Goyal L , Hawkins WG , Iyer R , Jacob R , Kelley RK , Kim R , Levine M , Palta M , Park JO , Raman S , Reddy S , Sahai V , Schefter T , Singh G , Stein S , Vauthey JN , Venook AP , Yopp A , McMillian NR , Hochstetler C , Darlow SD
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
J Natl Compr Canc Netw. 2021 May 1;19(5) :541-565
PMID: 34030131   
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Abstract
The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due to the multiple modalities that can be used to treat the disease and the complications that can arise from comorbid liver dysfunction, a multidisciplinary evaluation is essential for determining an optimal treatment strategy. A multidisciplinary team should include hepatologists, diagnostic radiologists, interventional radiologists, surgeons, medical oncologists, and pathologists with hepatobiliary cancer expertise. In addition to surgery, transplant, and intra-arterial therapies, there have been great advances in the systemic treatment of HCC. Until recently, sorafenib was the only systemic therapy option for patients with advanced HCC. In 2020, the combination of atezolizumab and bevacizumab became the first regimen to show superior survival to sorafenib, gaining it FDA approval as a new frontline standard regimen for unresectable or metastatic HCC. This article discusses the NCCN Guidelines recommendations for HCC.
Notes
1540-1413 Benson, Al B D'Angelica, Michael I Abbott, Daniel E Anaya, Daniel A Anders, Robert Are, Chandrakanth Bachini, Melinda Borad, Mitesh Brown, Daniel Burgoyne, Adam Chahal, Prabhleen Chang, Daniel T Cloyd, Jordan Covey, Anne M Glazer, Evan S Goyal, Lipika Hawkins, William G Iyer, Renuka Jacob, Rojymon Kelley, R Kate Kim, Robin Levine, Matthew Palta, Manisha Park, James O Raman, Steven Reddy, Sanjay Sahai, Vaibhav Schefter, Tracey Singh, Gagandeep Stein, Stacey Vauthey, Jean-Nicolas Venook, Alan P Yopp, Adam McMillian, Nicole R Hochstetler, Cindy Darlow, Susan D Journal Article United States J Natl Compr Canc Netw. 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022.