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Tempero MA , Malafa MP , Al-Hawary M , Behrman SW , Benson AB , Cardin DB , Chiorean EG , Chung V , Czito B , Del Chiaro M , Dillhoff M , Donahue TR , Dotan E , Ferrone CR , Fountzilas C , Hardacre J , Hawkins WG , Klute K , Ko AH , Kunstman JW , LoConte N , Lowy AM , Moravek C , Nakakura EK , Narang AK , Obando J , Polanco PM , Reddy S , Reyngold M , Scaife C , Shen J , Vollmer C , Wolff RA , Wolpin BM , Lynn B , George GV
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
J Natl Compr Canc Netw. 2021 Apr 1;19(4) :439-457
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Abstract
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.
Notes
Tempero, Margaret A Malafa, Mokenge P Al-Hawary, Mahmoud Behrman, Stephen W Benson, Al B Cardin, Dana B Chiorean, E Gabriela Chung, Vincent Czito, Brian Del Chiaro, Marco Dillhoff, Mary Donahue, Timothy R Dotan, Efrat Ferrone, Cristina R Fountzilas, Christos Hardacre, Jeffrey Hawkins, William G Klute, Kelsey Ko, Andrew H Kunstman, John W LoConte, Noelle Lowy, Andrew M Moravek, Cassadie Nakakura, Eric K Narang, Amol K Obando, Jorge Polanco, Patricio M Reddy, Sushanth Reyngold, Marsha Scaife, Courtney Shen, Jeanne Vollmer, Charles Wolff, Robert A Wolpin, Brian M Lynn, Beth George, Giby V eng J Natl Compr Canc Netw. 2021 Apr 1;19(4):439-457. doi: 10.6004/jnccn.2021.0017.