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Vickman RE , Faget DV , Beachy P , Beebe D , Bhowmick NA , Cukierman E , Deng WM , Granneman JG , Hildesheim J , Kalluri R , Lau KS , Lengyel E , Lundeberg J , Moscat J , Nelson PS , Pietras K , Politi K , Puré E , Scherz-Shouval R , Sherman MH , Tuveson D , Weeraratna AT , White RM , Wong MH , Woodhouse EC , Zheng Y , Hayward SW , Stewart SA
Deconstructing tumor heterogeneity: the stromal perspective
Oncotarget. 2020 Oct 6;11(40) :3621-3632
PMID: 33088423    PMCID: PMC7546755   
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Abstract
Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field.
Notes
1949-2553 Vickman, Renee E Faget, Douglas V Beachy, Philip Beebe, David Bhowmick, Neil A Cukierman, Edna Deng, Wu-Min Granneman, James G Hildesheim, Jeffrey Kalluri, Raghu Lau, Ken S Lengyel, Ernst Lundeberg, Joakim Moscat, Jorge Nelson, Peter S Pietras, Kristian Politi, Katerina Puré, Ellen Scherz-Shouval, Ruth Sherman, Mara H Tuveson, David Weeraratna, Ashani T White, Richard M Wong, Melissa H Woodhouse, Elisa C Zheng, Ying Hayward, Simon W Stewart, Sheila A Journal Article Oncotarget. 2020 Oct 6;11(40):3621-3632. doi: 10.18632/oncotarget.27736. eCollection 2020 Oct 6.