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Medulloblastoma cells resemble neuronal progenitors in their differentiation
Mol Cell Oncol. 2020 Sep 5;7(6) :1810514
PMID: 33235914 PMCID: PMC7671073 URL: https://www.ncbi.nlm.nih.gov/pubmed/33235914
AbstractMedulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.
NotesGuo, Duancheng Qu, Yanghui Yang, Yijun Yang, Zeng-Jie eng Mol Cell Oncol. 2020 Sep 5;7(6):1810514. doi: 10.1080/23723556.2020.1810514.