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Moscatello DK , Holgadomadruga M , Godwin AK , Ramirez G , Gunn G , Zoltick PW , Biegel JA , Hayes RL , Wong AJ
Frequent Expression of a Mutant Epidermal Growth-Factor Receptor in Multiple Human Tumors
Cancer Research. 1995 Dec 1;55(23) :5536-5539
PMID: ISI:A1995TG21100012   
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Abstract
The epidermal growth factor receptor has received much interest as a target for various antineoplastic agents, but a complication is that many normal tissues also express this receptor, We have previously identified in human glial tumors an 801-bp in-frame deletion within the epidermal growth factor receptor gene that created a novel epitope at the junction, By using Western blot assays with a mutant-specific antibody as a rapid and sensitive means for detecting this alteration in primary human tumors, it was found that 57% (26 of 46) of high- grade and 86% (6 of 7) of low-grade glial tumors, but not normal brain, express this protein, This altered receptor was also present in 66% (4 of 6) of pediatric gliomas and 86% (6 of 7) of medulloblastomas, 78% (21 of 27) of breast carcinomas, and 73% (24 of 32) of ovarian carcinomas. The fact that this receptor is frequently found in tumors but not in normal tissue makes it an attractive candidate for various antitumor strategies.
Notes
Times Cited: 120 Note TG211 CANCER RES