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Banzato TP , Gubiani JR , Bernardi DI , Nogueira CR , Monteiro AF , Juliano FF , de Alencar SM , Pilli RA , Lima CA , Longato GB , Ferreira AG , Foglio MA , Carvalho JE , Vendramini-Costa DB , Berlinck RGS
Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis
J Nat Prod. 2020 Jun 26;83(6) :1784-1793
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Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (5-7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (8), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.
1520-6025 Banzato, Thais P Gubiani, Juliana R Bernardi, Darlon I Nogueira, Claudio R ORCID: http://orcid.org/0000-0003-2267-4754 Monteiro, Afif F ORCID: http://orcid.org/0000-0002-6710-6139 Juliano, Fernanda F ORCID: http://orcid.org/0000-0002-3129-713X de Alencar, Severino M ORCID: http://orcid.org/0000-0002-6637-7973 Pilli, Ronaldo A ORCID: http://orcid.org/0000-0002-5919-7763 Lima, Carolina A de Longato, Giovanna B Ferreira, Antonio G Foglio, Mary Ann Carvalho, Joao E de Vendramini-Costa, Debora B Berlinck, Roberto G S ORCID: http://orcid.org/0000-0003-0118-2523 Journal Article United States J Nat Prod. 2020 Jun 26;83(6):1784-1793. doi: 10.1021/acs.jnatprod.9b01136. Epub 2020 Jun 11.