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Saad A , de Lima M , Anand S , Bhatt VR , Bookout R , Chen G , Couriel D , Di Stasi A , El-Jawahri A , Giralt S , Gutman J , Ho V , Horwitz M , Hsu J , Juckett M , Kharfan-Dabaja MA , Loren A , Meade J , Mielcarek M , Moreira J , Nakamura R , Nieto Y , Roddy J , Satyanarayana G , Schroeder M , Tan CR , Tzachanis D , Burn J , Pluchino L
Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology
J Natl Compr Canc Netw. 2020 May 1;18(5) :599-634
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Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor cells into patients with hematologic disorders with the goal of re-establishing normal hematopoietic and immune function. HCT is classified as autologous or allogeneic based on the origin of hematopoietic cells. Autologous HCT uses the patient's own cells while allogeneic HCT uses hematopoietic cells from a human leukocyte antigen-compatible donor. Allogeneic HCT is a potentially curative treatment option for patients with certain types of hematologic malignancies, and autologous HCT is primarily used to support patients undergoing high-dose chemotherapy. Advances in HCT methods and supportive care in recent decades have led to improved survival after HCT; however, disease relapse and posttransplant complications still commonly occur in both autologous and allogeneic HCT recipients. Allogeneic HCT recipients may also develop acute and/or chronic graft-versus-host disease (GVHD), which results in immune-mediated cellular injury of several organs. The NCCN Guidelines for Hematopoietic Cell Transplantation focus on recommendations for pretransplant recipient evaluation and the management of GVHD in adult patients with malignant disease.
Saad, Ayman de Lima, Marcos Anand, Sarah Bhatt, Vijaya Raj Bookout, Ryan Chen, George Couriel, Daniel Di Stasi, Antonio El-Jawahri, Areej Giralt, Sergio Gutman, Jonathan Ho, Vincent Horwitz, Mitchell Hsu, Joe Juckett, Mark Kharfan-Dabaja, Mohamed A. Loren, Alison Meade, Javier Mielcarek, Marco Moreira, Jonathan Nakamura, Ryotaro Nieto, Yago Roddy, Juliana Satyanarayana, Gowri Schroeder, Mark Tan, Carlyn Rose Tzachanis, Dimitrios Burn, Jennifer Pluchino, Lenora eng J Natl Compr Canc Netw. 2020 May 1;18(5):599-634. doi: 10.6004/jnccn.2020.0021.