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Liu F , Dai S , Feng D , Qin Z , Peng X , Sakamuri Ssvp , Ren M , Huang L , Cheng M , Mohammad KE , Qu P , Chen Y , Zhao C , Zhu F , Liang S , Aktas BH , Yang X , Wang H , Katakam PVG , Busija DW , Fischer T , Datta PK , Rappaport J , Gao B , Qin X
Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins
Nat Commun. 2020 May 8;11(1) :2280
PMID: 32385245    PMCID: PMC7210253    URL: https://www.ncbi.nlm.nih.gov/pubmed/32385245
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Abstract
Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs consist of embryo-derived (EMRMs) and bone marrow-derived RMs (BMRMs), but the fate, dynamics, replenishment, functions and metabolic states of these two RM populations remain unclear. Here we investigate and characterize RMs at different ages by conditionally labeling and ablating RMs populations in several transgenic lines. We find that RMs expand and mature in parallel with renal growth after birth, and are mainly derived from fetal liver monocytes before birth, but self-maintain through adulthood with contribution from peripheral monocytes. Moreover, after the RMs niche is emptied, peripheral monocytes rapidly differentiate into BMRMs, with the CX3CR1/CX3CL1 signaling axis being essential for the maintenance and regeneration of both EMRMs and BMRMs. Lastly, we show that EMRMs have a higher capacity for scavenging immune complex, and are more sensitive to immune challenge than BMRMs, with this difference associated with their distinct glycolytic capacities.
Notes
2041-1723 Liu, Fengming ORCID: http://orcid.org/0000-0002-8815-3356 Dai, Shen Feng, Dechun Qin, Zhongnan Peng, Xiao Sakamuri, Siva S V P Ren, Mi Huang, Li Cheng, Min Mohammad, Kabir E Qu, Ping Chen, Yong Zhao, Chunling Zhu, Faliang Liang, Shujian Aktas, Bertal H ORCID: http://orcid.org/0000-0001-7829-4553 Yang, Xiaofeng Wang, Hong Katakam, Prasad V G ORCID: http://orcid.org/0000-0002-4708-9140 Busija, David W Fischer, Tracy ORCID: http://orcid.org/0000-0003-4859-3776 Datta, Prasun K Rappaport, Jay Gao, Bin Qin, Xuebin ORCID: http://orcid.org/0000-0001-9875-983X R21OD024931/U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) R01 HL130233/HL/NHLBI NIH HHS/United States 5P51OD011104-58/U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) R01 NS094834/NS/NINDS NIH HHS/United States P20GM103629-08S1/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) PO1MH105303/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) Journal Article England Nat Commun. 2020 May 8;11(1):2280. doi: 10.1038/s41467-020-16158-z.