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Recent advances in understanding the development and function of gammadelta T cells
F1000Res. 2020 ;9
PMID: 32399190    PMCID: PMC7194461    URL: https://www.ncbi.nlm.nih.gov/pubmed/32399190
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Abstract
gammadelta T cells are a subset of T cells with attributes of both the innate and adaptive arms of the immune system. These cells have long been an enigmatic and poorly understood component of the immune system and many have viewed them as having limited importance in host defense. This perspective persisted for some time both because of critical gaps in knowledge regarding how the development of gammadelta T cells is regulated and because of the lack of effective and sophisticated approaches through which the function of gammadelta T cells can be manipulated. Here, we discuss the recent advances in both of these areas, which have brought the importance of gammadelta T cells in both productive and pathologic immune function more sharply into focus.
Notes
2046-1402 Contreras, Alejandra V ORCID: https://orcid.org/0000-0003-3653-5958 Wiest, David L ORCID: https://orcid.org/0000-0002-0792-3188 P01 AI102853/AI/NIAID NIH HHS/United States Journal Article Review England F1000Res. 2020 Apr 29;9. doi: 10.12688/f1000research.22161.1. eCollection 2020.