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Cancer Associated Fibroblast: Mediators of Tumorigenesis
Matrix Biol. 2020 May 22;91-92 :19-34
PMID: 32450219 PMCID: PMC7434664 URL: https://www.ncbi.nlm.nih.gov/pubmed/32450219
AbstractIt is well accepted that the tumor microenvironment plays a pivotal role in cancer onset, development, and progression. The majority of clinical interventions are designed to target either cancer or stroma cells. These emphases have been directed by one of two prevailing theories in the field, the Somatic Mutation Theory and the Tissue Organization Field Theory, which represent two seemingly opposing concepts. This review proposes that the two theories are mutually inclusive and should be concurrently considered for cancer treatments. Specifically, this review discusses the dynamic and reciprocal processes between stromal cells and extracellular matrices, using pancreatic cancer as an example, to demonstrate the inclusivity of the theories. Furthermore, this review highlights the functions of cancer associated fibroblast, which represent the major stromal cell, as important mediators of the known cancer hallmarks that the two theories attempt to explain.
Notes1569-1802 Alexander, Jennifer Cukierman, Edna R01 CA232256/CA/NCI NIH HHS/United States R21 CA231252/CA/NCI NIH HHS/United States Journal Article Netherlands Matrix Biol. 2020 May 22. pii: S0945-053X(20)30055-X. doi: 10.1016/j.matbio.2020.05.004.