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Knaus UG , Morris S , Dong HJ , Chernoff J , Bokoch GM
Regulation of Human-Leukocyte P21-Activated Kinases through G- Protein-Coupled Receptors
Science. 1995 Jul 14;269(5221) :221-223
AbstractThe Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the similar to 65- and similar to 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phos phorylated the p47(phox) reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.
NotesTimes Cited: 211 Article RJ029 SCIENCE