FCCC LOGO Faculty Publications
Kappes DJ , Alarcon B , Regueiro JR
T-Lymphocyte Receptor Deficiencies
Current Opinion in Immunology. 1995 Aug;7(4) :441-447
PMID: ISI:A1995RV08100003   
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Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.
Times Cited: 22 Review RV081 CURR OPIN IMMUNOL