This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Kappes DJ , Alarcon B , Regueiro JR
T-Lymphocyte Receptor Deficiencies
Current Opinion in Immunology. 1995 Aug;7(4) :441-447
AbstractSignalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.
NotesTimes Cited: 22 Review RV081 CURR OPIN IMMUNOL