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Feitelson MA , Duan LX , Guo J , Sun B , Woo J , Steensma K , Horiike N , Blumberg BS
X-Region Deletion Variants of Hepatitis-B Virus in Surface Antigen-Negative Infections and Non-a, Non-B-Hepatitis
Journal of Infectious Diseases. 1995 Sep;172(3) :713-722
PMID: ISI:A1995RR07300013   
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The etiology of non-A, non-B hepatitis (NANBH) in renal dialysis patients was determined. Hepatitis C virus was present in many, but its appearance did not correlate with elevated alanine aminotransaminase. When sera from these patients were tested for antibodies against hepatitis B virus (HBV) X antigen and polymerase, 70% were positive. HBV infection was confirmed by polymerase chain reaction using several HBV-specific primer pairs. However, amplification with X region primers failed to yield products in many patients. Cloning and sequencing of these products demonstrated deletions within the X region. Hence, X-deletion variants of HBV are strongly associated with NANBH in renal dialysis patients.
Times Cited: 20 Article RR073 J INFEC DIS