This is an archive of papers published by the staff and faculty of Fox Chase Cancer Center. For questions about content, please contact Talbot Research Library
Last updated on
Feitelson MA , Duan LX , Guo J , Sun B , Woo J , Steensma K , Horiike N , Blumberg BS
X-Region Deletion Variants of Hepatitis-B Virus in Surface Antigen-Negative Infections and Non-a, Non-B-Hepatitis
Journal of Infectious Diseases. 1995 Sep;172(3) :713-722
AbstractThe etiology of non-A, non-B hepatitis (NANBH) in renal dialysis patients was determined. Hepatitis C virus was present in many, but its appearance did not correlate with elevated alanine aminotransaminase. When sera from these patients were tested for antibodies against hepatitis B virus (HBV) X antigen and polymerase, 70% were positive. HBV infection was confirmed by polymerase chain reaction using several HBV-specific primer pairs. However, amplification with X region primers failed to yield products in many patients. Cloning and sequencing of these products demonstrated deletions within the X region. Hence, X-deletion variants of HBV are strongly associated with NANBH in renal dialysis patients.
NotesTimes Cited: 20 Article RR073 J INFEC DIS